InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfsf14

Summary

InnateDB Protein

IDBP-193747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfsf14

Protein Name

tumor necrosis factor (ligand) superfamily, member 14

Synonyms

HVEM-L; HVEML; LIGHT; LTg; Ly113;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005976

InnateDB Gene

IDBG-193745 (Tnfsf14)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0006955	immune response
GO:0008588	release of cytoplasmic sequestered NF-kappaB
GO:0010820	positive regulation of T cell chemotaxis
GO:0031295	T cell costimulation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071260	cellular response to mechanical stimulus