InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apip

Summary

InnateDB Protein

IDBP-193762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apip

Protein Name

APAF1 interacting protein

Synonyms

APIP2; CGI-29; Mmrp19;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000011055

InnateDB Gene

IDBG-193760 (Apip)

Protein Structure

UniProt Annotation

Function

Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255HAMAP-Rule:MF_03116, ECO:0000269PubMed:15262985, ECO:0000269PubMed:17086211}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03116}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle (at protein level). {ECO:0000269PubMed:15262985}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding
GO:0046570	methylthioribulose 1-phosphate dehydratase activity
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0019284	L-methionine biosynthetic process from S-adenosylmethionine
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0043066	negative regulation of apoptotic process
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005575	cellular_component
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1926788

InterPro

IPR001303 Class II aldolase/adducin N-terminal
IPR017714 Methylthioribulose-1-phosphate dehydratase

PFAM

PF00596

PRINTS

PIRSF

SMART

SM01007

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WVQ5

PhosphoSite

PhosphoSite-Q9WVQ5

TrEMBL

UniProt Splice Variant

Entrez Gene

56369

UniGene

RefSeq

NP_062709

MGI ID

MGI Symbol

Apip

OMIM

CCDS

CCDS16474

HPRD

IMGT

EMBL

AB028863 AK077705 AK145450 BC028434

GenPept

AAH28434 BAA78906 BAC36968 BAE26445