Version 5.4
Homo sapiens Protein: BCL11B
Summary
InnateDB Protein IDBP-19379.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL11B
Protein Name B-cell CLL/lymphoma 11B (zinc finger protein)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000280435
InnateDB Gene IDBG-19375 (BCL11B)
Protein Structure
UniProt Annotation
Function Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9C0K0
PhosphoSite PhosphoSite-Q9C0K0
TrEMBL L8B567
UniProt Splice Variant
Entrez Gene 64919
UniGene Hs.709690
RefSeq NP_075049
HUGO HGNC:13222
OMIM 606558
CCDS CCDS9949
HPRD 05950
IMGT
EMBL AB043584 AB057669 AJ404614 CH471061
GenPept BAB32731 BAM78284 CAC17726 EAW81662

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca