Version 5.4
Mus musculus Protein: Bcl6b
Summary
InnateDB Protein IDBP-193815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcl6b
Protein Name B-cell CLL/lymphoma 6, member B
Synonyms Bazf;
Species Mus musculus
Ensembl Protein ENSMUSP00000000326
InnateDB Gene IDBG-193813 (Bcl6b)
Protein Structure
UniProt Annotation
Function Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6. {ECO:0000269PubMed:15314041, ECO:0000269PubMed:9632807}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Ubiquitously expressed with higher expression found in heart and lung. {ECO:0000269PubMed:9632807}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1278332
InterPro IPR000210 BTB/POZ-like
IPR007087 Zinc finger, C2H2
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PF00651
PRINTS
PIRSF
SMART SM00225
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88282
PhosphoSite PhosphoSite-O88282
TrEMBL Q5BKP3
UniProt Splice Variant
Entrez Gene 12029
UniGene Mm.405470
RefSeq NP_031554
MGI ID
MGI Symbol Bcl6b
OMIM
CCDS CCDS24939
HPRD
IMGT
EMBL AB011665 AK032647 AL669869 BC090998 CH466596
GenPept AAH90998 BAA31223 BAC27970 EDL12540

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca