InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp6

Summary

InnateDB Protein

IDBP-193832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp6

Protein Name

caspase 6

Synonyms

mCASP-6; Mch2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029626

InnateDB Gene

IDBG-193830 (Casp6)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in lung, liver, kidney, testis, and heart. Lower levels in spleen, skeletal muscle and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0042802	identical protein binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0030855	epithelial cell differentiation
GO:0042981	regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1312921

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF00656

PRINTS

PR00376

PIRSF

SMART

SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt