InnateDB Protein
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IDBP-193859.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rcc1
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Protein Name
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regulator of chromosome condensation 1
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Synonyms
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4931417M11Rik; AI326872; Chc1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000081271
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InnateDB Gene
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IDBG-193857 (Rcc1)
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Protein Structure
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Function |
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Becomes dispersed throughout the cytoplasm during mitosis. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
55 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913989
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InterPro |
IPR000408
Regulator of chromosome condensation, RCC1
IPR009091
Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
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PFAM |
PF00415
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PRINTS |
PR00633
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VE37
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PhosphoSite |
PhosphoSite-Q8VE37
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TrEMBL |
A2CER2
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UniProt Splice Variant |
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Entrez Gene |
100088
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UniGene |
Mm.408324
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RefSeq |
NP_598639
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MGI ID |
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MGI Symbol |
Rcc1
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OMIM |
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CCDS |
CCDS18723
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HPRD |
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IMGT |
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EMBL |
AK150153
AL805897
BC019807
CR752656
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GenPept |
AAH19807
BAE29345
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