InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tas2r140

Summary

InnateDB Protein

IDBP-193883.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tas2r140

Protein Name

taste receptor, type 2, member 140

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093040

InnateDB Gene

IDBG-193881 (Tas2r140)

Protein Structure

UniProt Annotation

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008527	taste receptor activity

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050909	sensory perception of taste