InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tsfm

Summary

InnateDB Protein

IDBP-193941.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tsfm

Protein Name

Ts translation elongation factor, mitochondrial

Synonyms

2310050B20Rik; 9430024O13Rik; EF-TS; EF-Tsmt;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042134

InnateDB Gene

IDBG-193939 (Tsfm)

Protein Structure

UniProt Annotation

Function

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. {ECO:0000255HAMAP-Rule:MF_03135}.

Subcellular Localization

Mitochondrion {ECO:0000255HAMAP- Rule:MF_03135}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006414

translational elongation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1913649

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR009060 UBA-like
IPR014039 Translation elongation factor EFTs/EF1B, dimerisation

PFAM

PF00627
PF00889

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CZR8

PhosphoSite