InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mettl1

Summary

InnateDB Protein

IDBP-193993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mettl1

Protein Name

methyltransferase like 1

Synonyms

2810012D02Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006915

InnateDB Gene

IDBG-193991 (Mettl1)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. {ECO:0000255HAMAP-Rule:MF_03055}.

Subcellular Localization

Nucleus {ECO:0000255HAMAP-Rule:MF_03055}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0005515	protein binding
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity

Biological Process

GO:0006400	tRNA modification
GO:0030488	tRNA methylation
GO:0036265	RNA (guanine-N7)-methylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1339986

InterPro

IPR003358 tRNA (guanine-N-7) methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02390

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z120

PhosphoSite

PhosphoSite-Q9Z120

TrEMBL

D3YXU6

UniProt Splice Variant

Entrez Gene

17299

UniGene

Mm.487353

RefSeq

NP_034922

MGI ID

MGI Symbol

Mettl1

OMIM

CCDS

CCDS24223

HPRD

IMGT

EMBL

AB023619 AC134329 AK160914 BC012649 CH466578 Y18644

GenPept

AAH12649 BAA75230 BAE36088 CAA77240 EDL24462