Version 5.4
Mus musculus Protein: Cntnap4
Summary
InnateDB Protein IDBP-194002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cntnap4
Protein Name contactin associated protein-like 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000034225
InnateDB Gene IDBG-194000 (Cntnap4)
Protein Structure
UniProt Annotation
Function Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system. {ECO:0000269PubMed:24870235}.
Subcellular Localization Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:24870235}; Single-pass type I membrane protein {ECO:0000269PubMed:24870235}. Note=Specifically present within the presynaptic compartment of synapses.
Disease Associations
Tissue Specificity Specifically present in developing cortical interneurons: highly expressed in cortical parvalbumin (PV) cells and midbrain dopaminergic neurons and is localized presynaptically (at protein level). Also present in the substantia nigra pars compacta (SnC) and ventral tegmental area (VTA) midbrain dopaminergic projection populations. {ECO:0000269PubMed:24870235}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0032225 regulation of synaptic transmission, dopaminergic
GO:0032228 regulation of synaptic transmission, GABAergic
GO:2000821 regulation of grooming behavior
Cellular Component
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0042734 presynaptic membrane
Protein Structure and Domains
PDB ID MGI:2183572
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00754
PF00008
PF00054
PF02210
PF00147
PRINTS
PIRSF
SMART SM00231
SM00181
SM00210
SM00282
SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99P47
PhosphoSite PhosphoSite-Q99P47
TrEMBL Q69ZB1
UniProt Splice Variant
Entrez Gene 170571
UniGene Mm.401351
RefSeq NP_569724
MGI ID
MGI Symbol Cntnap4
OMIM
CCDS CCDS40482
HPRD
IMGT
EMBL AF333770 AK142816 AK173255 BC034628 CH466525
GenPept AAG52890 AAH34628 BAD32533 BAE25200 EDL11532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca