InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trip10

Summary

InnateDB Protein

IDBP-194021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trip10

Protein Name

thyroid hormone receptor interactor 10

Synonyms

AI646975; Cip4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019631

InnateDB Gene

IDBG-194019 (Trip10)

Protein Structure

UniProt Annotation

Function

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL (By similarity). Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. {ECO:0000250, ECO:0000269PubMed:12242347, ECO:0000269PubMed:16418535}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus {ECO:0000250}. Cell membrane. Cell projection, phagocytic cup {ECO:0000250}. Note=Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9 (By similarity). Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0042802	identical protein binding

Biological Process

GO:0006897	endocytosis
GO:0030036	actin cytoskeleton organization

Cellular Component

GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005764	lysosome
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0005938	cell cortex
GO:0042995	cell projection
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2146901

InterPro

IPR001060 FCH domain
IPR001452 SH3 domain

PFAM

PF00611
PF00018
PF14604

PRINTS

PR00452

PIRSF

SMART

SM00055
SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CJ53

PhosphoSite

PhosphoSite-Q8CJ53

TrEMBL

UniProt Splice Variant

Entrez Gene

106628

UniGene

RefSeq

NP_598886

MGI ID

MGI Symbol

Trip10

OMIM

CCDS

CCDS28930

HPRD

IMGT

EMBL

AF502565 AK088909 AK149902 AY081142 BC003249

GenPept

AAH03249 AAL89589 AAN38709 BAC40648 BAE29155