Version 5.4
Mus musculus Protein: Amotl2
Summary
InnateDB Protein IDBP-194032.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Amotl2
Protein Name angiomotin-like 2
Synonyms AW549739; C79691; Lccp; MASCOT; mKIAA0989;
Species Mus musculus
Ensembl Protein ENSMUSP00000035121
InnateDB Gene IDBG-194030 (Amotl2)
Protein Structure
UniProt Annotation
Function Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity). {ECO:0000250}.
Subcellular Localization Recycling endosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005923 tight junction
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID MGI:1929286
InterPro IPR009114 Angiomotin
IPR024646 Angiomotin, C-terminal
PFAM PF12240
PRINTS PR01807
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K371
PhosphoSite PhosphoSite-Q8K371
TrEMBL B8JK85
UniProt Splice Variant
Entrez Gene 56332
UniGene Mm.474629
RefSeq NP_062738
MGI ID
MGI Symbol Amotl2
OMIM
CCDS CCDS40745
HPRD
IMGT
EMBL AF175967 AF175968 AK040912 AK077535 AK141348 AK164279 BC027824 CH466560 CT573150
GenPept AAD56362 AAD56363 AAH27824 BAC30740 BAC36853 BAE24658 BAE37715 CAX15827 EDL21058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca