InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nat10

Summary

InnateDB Protein

IDBP-194038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nat10

Protein Name

N-acetyltransferase 10

Synonyms

AI429152;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028608

InnateDB Gene

IDBG-194036 (Nat10)

Protein Structure

UniProt Annotation

Function

Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0008080	N-acetyltransferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0008150	biological_process
GO:0008152	metabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2138939

InterPro

IPR000182 GNAT domain
IPR007807 Helicase domain
IPR013562 Domain of unknown function DUF1726
IPR016181 Acyl-CoA N-acyltransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM