InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atpif1

Summary

InnateDB Protein

IDBP-194055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atpif1

Protein Name

ATPase inhibitory factor 1

Synonyms

Atpi; If1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064282

InnateDB Gene

IDBG-194053 (Atpif1)

Protein Structure

UniProt Annotation

Function

Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000250, ECO:0000269PubMed:23135403}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0042030	ATPase inhibitor activity
GO:0042803	protein homodimerization activity
GO:0043532	angiostatin binding
GO:0051117	ATPase binding

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006783	heme biosynthetic process
GO:0030218	erythrocyte differentiation
GO:0043086	negative regulation of catalytic activity
GO:0045980	negative regulation of nucleotide metabolic process
GO:0051260	protein homooligomerization
GO:0051289	protein homotetramerization
GO:0051346	negative regulation of hydrolase activity
GO:0072593	reactive oxygen species metabolic process
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway