InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ryk

Summary

InnateDB Protein

IDBP-194081.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ryk

Protein Name

receptor-like tyrosine kinase

Synonyms

AW536699; ERK-3; Vik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035142

InnateDB Gene

IDBG-194079 (Ryk)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017147	Wnt-protein binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007409	axonogenesis
GO:0016055	Wnt signaling pathway
GO:0043410	positive regulation of MAPK cascade
GO:0048705	skeletal system morphogenesis
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0071679	commissural neuron axon guidance

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:101766

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003306 WIF domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF02019

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00469
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt