InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rhcg

Summary

InnateDB Protein

IDBP-194084.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rhcg

Protein Name

Rhesus blood group-associated C glycoprotein

Synonyms

BB065800;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032766

InnateDB Gene

IDBG-194082 (Rhcg)

Protein Structure

UniProt Annotation

Function

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion. {ECO:0000269PubMed:16131648}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:12388412, ECO:0000269PubMed:15576624}; Multi- pass membrane protein {ECO:0000269PubMed:12388412, ECO:0000269PubMed:15576624}. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the forestomach and the fundus of the stomach. Expressed at the level of villous in duodenum, jejunum, ileum and colon. Expressed in kidney by connecting segments and collecting tubules (at protein level). Expressed in testis by seminiferous tubules. {ECO:0000269PubMed:10852913, ECO:0000269PubMed:12388412, ECO:0000269PubMed:15576624}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008519	ammonium transmembrane transporter activity
GO:0030506	ankyrin binding

Biological Process

GO:0006873	cellular ion homeostasis
GO:0006885	regulation of pH
GO:0015696	ammonium transport
GO:0070634	transepithelial ammonium transport
GO:0072488	ammonium transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome