InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vav1

Summary

InnateDB Protein

IDBP-194095.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vav1

Protein Name

vav 1 oncogene

Synonyms

Vav; vav-T;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005889

InnateDB Gene

IDBG-194093 (Vav1)

Protein Structure

UniProt Annotation

Function

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed in hematopoietic cells but not in other cell types. Found in the spleen and lung. {ECO:0000269PubMed:2069873}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006909	phagocytosis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0030217	T cell differentiation
GO:0030593	neutrophil chemotaxis
GO:0032314	regulation of Rac GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042110	T cell activation
GO:0043087	regulation of GTPase activity
GO:0045785	positive regulation of cell adhesion
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005829	cytosol
GO:0005911	cell-cell junction

Protein Structure and Domains

PDB ID

MGI:98923

InterPro

IPR000219 Dbl homology (DH) domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR003096 Smooth muscle protein/calponin
IPR011511 Variant SH3 domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM