InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptafr

Summary

InnateDB Protein

IDBP-194113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptafr

Protein Name

platelet-activating factor receptor

Synonyms

PAFR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070925

InnateDB Gene

IDBG-194111 (Ptafr)

Protein Structure

UniProt Annotation

Function

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Found in a range of organs. Expressed most strongly in spleen, followed by skeletal muscle, lung and small intestine. Expressed at moderate levels in the heart. Expressed at relatively low levels in the brain, liver and kidney. {ECO:0000269PubMed:8670084}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001875	lipopolysaccharide receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004992	platelet activating factor receptor activity
GO:0005543	phospholipid binding

Biological Process

GO:0001816	cytokine production
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032959	inositol trisphosphate biosynthetic process
GO:0048015	phosphatidylinositol-mediated signaling