InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Caprin1

Summary

InnateDB Protein

IDBP-194158.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Caprin1

Protein Name

cell cycle associated protein 1

Synonyms

AL022980; Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137; rng105;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028607

InnateDB Gene

IDBG-194156 (Caprin1)

Protein Structure

UniProt Annotation

Function

May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. {ECO:0000269PubMed:20516077}.

Subcellular Localization

Cytoplasm, cytosol. Cell projection, dendrite. Note=Associated with RNA granules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest expression in thymus, spleen and brain (at protein level). Lower levels in kidney, muscle and liver (at protein level). {ECO:0000269PubMed:14764709, ECO:0000269PubMed:20516077}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0017148	negative regulation of translation
GO:0050775	positive regulation of dendrite morphogenesis
GO:0061003	positive regulation of dendritic spine morphogenesis

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0030425	dendrite