InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pelp1

Summary

InnateDB Protein

IDBP-194169.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pelp1

Protein Name

proline, glutamic acid and leucine rich protein 1

Synonyms

4930563C04Rik; MNAR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019065

InnateDB Gene

IDBG-194167 (Pelp1)

Protein Structure

UniProt Annotation

Function

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K (By similarity). Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000250, ECO:0000269PubMed:22872859}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:22872859}. Nucleus, nucleoplasm {ECO:0000269PubMed:22872859}. Cytoplasm {ECO:0000269PubMed:22872859}. Note=Also found associated with the plasma membrane (By similarity). Mainly found in the nucleoplasm, with low levels detected in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with high levels in testis, ovary, uterus and pituitary gland. {ECO:0000269PubMed:11481323}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008150	biological_process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0071339	MLL1 complex

Protein Structure and Domains

PDB ID

MGI:1922523

InterPro

IPR012980 Uncharacterised domain NUC202
IPR016024 Armadillo-type fold

PFAM

PF08166

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DBD5

PhosphoSite

PhosphoSite-Q9DBD5

TrEMBL

UniProt Splice Variant

Entrez Gene

75273

UniGene

Mm.340601

RefSeq

NP_083507

MGI ID

MGI Symbol

Pelp1

OMIM

CCDS

CCDS24945

HPRD

IMGT

EMBL

AK005027 AL596096 BC016444 BC057987 BC090620

GenPept

AAH16444 AAH57987 AAH90620 BAB23754 CAI51981