InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Emr1

Summary

InnateDB Protein

IDBP-194198.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Emr1

Protein Name

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

Synonyms

DD7A5-7; EGF-TM7; F4/80; Gpf480; Ly71; TM7LN3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004850

InnateDB Gene

IDBG-194190 (Emr1)

Protein Structure

UniProt Annotation

Function

Could be involved in cell-cell interactions.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:106912

InterPro

IPR000203 GPS motif
IPR000742 Epidermal growth factor-like domain
IPR000832 GPCR, family 2, secretin-like
IPR001740 GPCR, family 2, EMR1 hormone receptor
IPR001881 EGF-like calcium-binding domain
IPR017981 GPCR, family 2-like

PFAM

PF01825
PF00008
PF00002
PF07645

PRINTS

PR00249
PR01128

PIRSF

SMART

SM00303
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt