InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2t

Summary

InnateDB Protein

IDBP-194215.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2t

Protein Name

ubiquitin-conjugating enzyme E2T (putative)

Synonyms

2700084L22Rik; C80607;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027687

InnateDB Gene

IDBG-194213 (Ube2t)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Accumulates to chromatin. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006281	DNA repair
GO:0006513	protein monoubiquitination
GO:0006974	cellular response to DNA damage stimulus
GO:0035519	protein K29-linked ubiquitination
GO:0044314	protein K27-linked ubiquitination
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0085020	protein K6-linked ubiquitination

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:1914446

InterPro

IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like

PFAM

PF00179

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQ37

PhosphoSite

PhosphoSite-Q9CQ37

TrEMBL

UniProt Splice Variant

Entrez Gene

67196

UniGene

RefSeq

NP_080300

MGI ID

MGI Symbol

Ube2t

OMIM

CCDS

CCDS15313

HPRD

IMGT

EMBL

AK012565 AK021213 BC029213

GenPept

AAH29213 BAB28320 BAB32332