Version 5.4
Mus musculus Protein: Plin1
Summary
InnateDB Protein IDBP-194227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plin1
Protein Name perilipin 1
Synonyms 6030432J05Rik; Peri; Plin;
Species Mus musculus
Ensembl Protein ENSMUSP00000032762
InnateDB Gene IDBG-194223 (Plin1)
Protein Structure
UniProt Annotation
Function Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000250, ECO:0000269PubMed:23481402}.
Subcellular Localization Endoplasmic reticulum {ECO:0000250}. Lipid droplet {ECO:0000269PubMed:23481402}. Note=Lipid droplet surface- associated.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005811 lipid particle
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1890505
InterPro IPR004279 Perilipin
PFAM PF03036
PRINTS
PIRSF PIRSF036881
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CGN5
PhosphoSite PhosphoSite-Q8CGN5
TrEMBL
UniProt Splice Variant
Entrez Gene 103968
UniGene Mm.254917
RefSeq NP_783571
MGI ID
MGI Symbol Plin1
OMIM
CCDS CCDS21385
HPRD
IMGT
EMBL AK031445 AY161165 BC096685 CH466543
GenPept AAH96685 AAN77870 BAC27409 EDL07055

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca