InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arrb2

Summary

InnateDB Protein

IDBP-194256.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Arrb2

Protein Name

arrestin, beta 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082018

InnateDB Gene

IDBG-194248 (Arrb2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 292 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	292 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019904	protein domain specific binding
GO:0031625	ubiquitin protein ligase binding
GO:0031691	alpha-1A adrenergic receptor binding
GO:0031692	alpha-1B adrenergic receptor binding
GO:0031702	type 1 angiotensin receptor binding
GO:0031748	D1 dopamine receptor binding
GO:0031762	follicle-stimulating hormone receptor binding
GO:0031826	type 2A serotonin receptor binding
GO:0032403	protein complex binding
GO:0032947	protein complex scaffold
GO:0051019	mitogen-activated protein kinase binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0002031	G-protein coupled receptor internalization
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092	positive regulation of receptor internalization
GO:0006309	apoptotic DNA fragmentation
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007420	brain development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016567	protein ubiquitination
GO:0031397	negative regulation of protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0034260	negative regulation of GTPase activity
GO:0034392	negative regulation of smooth muscle cell apoptotic process
GO:0042699	follicle-stimulating hormone signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051897	positive regulation of protein kinase B signaling
GO:0051928	positive regulation of calcium ion transport
GO:0060326	cell chemotaxis
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0014069	postsynaptic density
GO:0016323	basolateral plasma membrane
GO:0030139	endocytic vesicle
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:99474

InterPro

IPR000698 Arrestin
IPR011021 Arrestin-like, N-terminal
IPR011022 Arrestin C-terminal-like domain
IPR014756 Immunoglobulin E-set

PFAM

PF00339
PF02752

PRINTS

PR00309

PIRSF

SMART

SM01017

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q5F2D9

UniProt Splice Variant

Entrez Gene

216869

UniGene

Mm.488859

RefSeq

MGI ID

MGI Symbol

Arrb2

OMIM

CCDS

HPRD

IMGT

EMBL

AL596096 CR936841

GenPept

CAM28186