InnateDB Protein
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IDBP-194393.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Anpep
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Protein Name
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alanyl (membrane) aminopeptidase
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Synonyms
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AP-M; AP-N; Apn; Cd13; P150;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000035943
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InnateDB Gene
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IDBG-194391 (Anpep)
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Protein Structure
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Function |
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May have a role in angiogenesis (By similarity). Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells. {ECO:0000250, ECO:0000269PubMed:8103749}.
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Subcellular Localization |
Membrane; Single-pass type II membrane protein.
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Disease Associations |
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Tissue Specificity |
Highly expressed in intestinal tract and kidney, present in liver, lymph node, spleen, and brain. Found as well in monocytes, macrophages, dendritic cells, veiled cells and B-cells but not on T-cells and thymocytes. {ECO:0000269PubMed:8805662}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:5000466
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InterPro |
IPR014782
Peptidase M1, membrane alanine aminopeptidase, N-terminal
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PFAM |
PF01433
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PRINTS |
PR00756
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P97449
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PhosphoSite |
PhosphoSite-P97449
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TrEMBL |
Q3TB69
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UniProt Splice Variant |
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Entrez Gene |
16790
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UniGene |
Mm.4487
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RefSeq |
NP_032512
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MGI ID |
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MGI Symbol |
Anpep
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OMIM |
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CCDS |
CCDS21388
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HPRD |
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IMGT |
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EMBL |
AK171427
BC005431
BC017011
BC040792
U77083
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GenPept |
AAB19065
AAH05431
AAH17011
AAH40792
BAE42445
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