Version 5.4
Mus musculus Protein: Themis2
Summary
InnateDB Protein IDBP-194419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Themis2
Protein Name cDNA sequence BC013712
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036945
InnateDB Gene IDBG-194417 (Themis2)
Protein Structure
UniProt Annotation
Function May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. {ECO:0000269PubMed:20644716}.
Subcellular Localization
Disease Associations
Tissue Specificity Restricted to B-cells, macrophages and dendritic cells. Down-regulated in splenocytes of mice developing arthritis in a collagen-induced model, not in those of mice failing to develop the disease. Transiently down-regulated in splenocytes of mice infected with influenza virus. {ECO:0000269PubMed:19597499}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2446213
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YX0
PhosphoSite PhosphoSite-Q91YX0
TrEMBL
UniProt Splice Variant
Entrez Gene 230787
UniGene
RefSeq NP_001028480
MGI ID
MGI Symbol Themis2
OMIM
CCDS CCDS18735
HPRD
IMGT
EMBL AK150471 AK153536 AK155536 AK171009 AL627130 AL671190 BC013712 BC151122 BC151126
GenPept AAH13712 AAI51123 AAI51127 BAE29588 BAE32073 BAE33313 BAE42180 CAM24493 CAM25193

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca