InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgms2

Summary

InnateDB Protein

IDBP-194436.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgms2

Protein Name

sphingomyelin synthase 2

Synonyms

4933405A16Rik; 5133401H06Rik; AI854299;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087713

InnateDB Gene

IDBG-194434 (Sgms2)

Protein Structure

UniProt Annotation

Function

Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. {ECO:0000269PubMed:19590047, ECO:0000269PubMed:21844222, ECO:0000269PubMed:22580896, ECO:0000269PubMed:22849442}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly plasma membrane, some in Golgi apparatus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in liver and macrophages. {ECO:0000269PubMed:19590047}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0016301	kinase activity
GO:0033188	sphingomyelin synthase activity
GO:0047493	ceramide cholinephosphotransferase activity

Biological Process

GO:0006686	sphingomyelin biosynthetic process
GO:0016310	phosphorylation

Cellular Component

GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030173	integral component of Golgi membrane
GO:0045203	integral component of cell outer membrane