InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr37l1

Summary

InnateDB Protein

IDBP-194439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr37l1

Protein Name

G protein-coupled receptor 37-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027682

InnateDB Gene

IDBG-194437 (Gpr37l1)

Protein Structure

UniProt Annotation

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in brain. {ECO:0000269Ref.1}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0021940	positive regulation of cerebellar granule cell precursor proliferation
GO:0045665	negative regulation of neuron differentiation
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048712	negative regulation of astrocyte differentiation