InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wwox

Summary

InnateDB Protein

IDBP-194460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wwox

Protein Name

WW domain-containing oxidoreductase

Synonyms

5330426P09Rik; 9030416C10Rik; WOX1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004756

InnateDB Gene

IDBG-194458 (Wwox)

Protein Structure

UniProt Annotation

Function

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)- mediated cell death. Required for normal bone development. {ECO:0000250, ECO:0000269PubMed:11058590, ECO:0000269PubMed:19366691}.

Subcellular Localization

Cytoplasm. Nucleus. Mitochondrion {ECO:0000250}. Note=Partially localizes to the mitochondria (By similarity). Translocates to the nucleus in response to TGFB1 (By similarity). Translocates to the nucleus upon genotoxic stress or TNF stimulation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. In the brain, expressed in cortex, striatum, hippocampus and cerebellum (at protein level). Detected in embryonic skeleton, in cranofacial bones, vertebrae and limb bones. Detected in chondrocytes and osteoblasts. {ECO:0000269PubMed:15026124, ECO:0000269PubMed:17360458, ECO:0000269PubMed:18487609}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0019899	enzyme binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0008152	metabolic process
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048705	skeletal system morphogenesis
GO:0055114	oxidation-reduction process
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand