InnateDB Protein
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IDBP-194582.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Aimp1
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Protein Name
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aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
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Synonyms
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9830137A06Rik; AIMP1/p43; Emap2; EMAPII; p43; Scye1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000029663
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InnateDB Gene
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IDBG-194580 (Aimp1)
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Protein Structure
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Function |
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle. Secreted. Endoplasmic reticulum. Golgi apparatus. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels. Also secreted in response to hypoxia and both apoptotic and necrotic cell death.
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Disease Associations |
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Tissue Specificity |
Highly expressed in salivary glands and pancreatic alpha cells in the adult (at protein level). In the embryo, expressed primarily at sites of tissue remodeling such as ganglia, developing bones and teeth. {ECO:0000269PubMed:17001013, ECO:0000269PubMed:9770485}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:102774
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InterPro |
IPR002547
tRNA-binding domain
IPR010989
t-SNARE
IPR012340
Nucleic acid-binding, OB-fold
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PFAM |
PF01588
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P31230
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PhosphoSite |
PhosphoSite-P31230
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TrEMBL |
Q3UZG4
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UniProt Splice Variant |
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Entrez Gene |
13722
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UniGene |
Mm.235137
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RefSeq |
NP_031952
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MGI ID |
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MGI Symbol |
Aimp1
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OMIM |
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CCDS |
CCDS38642
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HPRD |
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IMGT |
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EMBL |
AC135118
AK133859
AK160506
BC002054
U10118
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GenPept |
AAA62203
AAH02054
BAE21893
BAE35830
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