Version 5.4
Mus musculus Protein: Psmb6
Summary
InnateDB Protein IDBP-194625.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmb6
Protein Name proteasome (prosome, macropain) subunit, beta type 6
Synonyms Lmp19; Mpnd;
Species Mus musculus
Ensembl Protein ENSMUSP00000018430
InnateDB Gene IDBG-194623 (Psmb6)
Protein Structure
UniProt Annotation
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:104880
InterPro IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 Proteasome, subunit alpha/beta
IPR029055 Nucleophile aminohydrolases, N-terminal
PFAM PF00227
PRINTS PR00141
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60692
PhosphoSite PhosphoSite-Q60692
TrEMBL
UniProt Splice Variant
Entrez Gene 19175
UniGene Mm.98
RefSeq NP_032972
MGI ID 3UNE
MGI Symbol Psmb6
OMIM
CCDS CCDS48836
HPRD
IMGT
EMBL AK078437 AK132042 AK167123 AK167227 AL592547 BC013897 U13393 U13394
GenPept AAA75375 AAA75376 AAH13897 BAC37272 BAE20959 BAE39271 BAE39351 CAI24014

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca