InnateDB Protein
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IDBP-194714.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cib1
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Protein Name
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calcium and integrin binding 1 (calmyrin)
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Synonyms
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Cibkip; Kip; Prkdcip;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000070901
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InnateDB Gene
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IDBG-194710 (Cib1)
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Protein Structure
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Function |
Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin- stimulated megakaryocytes preventing platelet aggregation. Up- regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N- myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells. {ECO:0000269PubMed:16982698, ECO:0000269PubMed:17975111, ECO:0000269PubMed:19691476, ECO:0000269PubMed:20804551, ECO:0000269PubMed:22128142}.
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Subcellular Localization |
Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell membrane. Cell membrane, sarcolemma. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, filopodium tip {ECO:0000250}. Apical cell membrane {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalized with NBR1 to the perinuclear region (By similarity). Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium- dependent manner. Colocalized with STMN2 in the cell body, neurites and growth cones of neurons. Colocalized with STMN2 to the leading edge of lamellipodia. Colocalizes with PLK3 at the centrosomes in ductal breast carcinoma cells (By similarity). Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in testis. Expressed in cardiac myocytes and endothelial cells. Expressed strongly in Sertoli cells, weakly in pachytene spermatocytes, round spermatids and condensing spermatids (at protein level). Ubiquitous. {ECO:0000269PubMed:17975111, ECO:0000269PubMed:18989529, ECO:0000269PubMed:20639889}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
GO:0001525
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angiogenesis
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GO:0001933
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negative regulation of protein phosphorylation
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GO:0001934
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positive regulation of protein phosphorylation
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GO:0001954
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positive regulation of cell-matrix adhesion
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GO:0002931
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response to ischemia
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GO:0006915
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apoptotic process
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GO:0006974
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cellular response to DNA damage stimulus
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GO:0007026
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negative regulation of microtubule depolymerization
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GO:0007113
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endomitotic cell cycle
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GO:0007155
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cell adhesion
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GO:0007286
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spermatid development
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GO:0008284
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positive regulation of cell proliferation
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GO:0008285
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negative regulation of cell proliferation
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GO:0010977
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negative regulation of neuron projection development
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GO:0030220
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platelet formation
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GO:0030307
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positive regulation of cell growth
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GO:0030335
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positive regulation of cell migration
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GO:0031122
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cytoplasmic microtubule organization
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GO:0033630
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positive regulation of cell adhesion mediated by integrin
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GO:0038163
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thrombopoietin-mediated signaling pathway
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GO:0042127
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regulation of cell proliferation
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GO:0043066
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negative regulation of apoptotic process
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GO:0045653
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negative regulation of megakaryocyte differentiation
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GO:0048554
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positive regulation of metalloenzyme activity
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GO:0051092
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positive regulation of NF-kappaB transcription factor activity
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GO:0051301
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cell division
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GO:0051302
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regulation of cell division
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GO:0051898
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negative regulation of protein kinase B signaling
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GO:0070374
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positive regulation of ERK1 and ERK2 cascade
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GO:0070886
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positive regulation of calcineurin-NFAT signaling cascade
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GO:0071356
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cellular response to tumor necrosis factor
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GO:0071363
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cellular response to growth factor stimulus
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GO:0071902
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positive regulation of protein serine/threonine kinase activity
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GO:0090004
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positive regulation of establishment of protein localization to plasma membrane
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GO:0090050
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positive regulation of cell migration involved in sprouting angiogenesis
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GO:0090314
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positive regulation of protein targeting to membrane
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GO:1900026
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positive regulation of substrate adhesion-dependent cell spreading
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GO:1901313
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positive regulation of gene expression involved in extracellular matrix organization
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GO:1990090
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cellular response to nerve growth factor stimulus
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GO:2000256
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positive regulation of male germ cell proliferation
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Cellular Component |
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PDB ID |
MGI:1344418
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InterPro |
IPR002048
EF-hand domain
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PFAM |
PF00036
PF13202
PF13405
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PRINTS |
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PIRSF |
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SMART |
SM00054
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z0F4
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PhosphoSite |
PhosphoSite-
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TrEMBL |
D3YY46
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UniProt Splice Variant |
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Entrez Gene |
23991
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UniGene |
Mm.445243
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RefSeq |
NP_036000
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MGI ID |
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MGI Symbol |
Cib1
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OMIM |
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CCDS |
CCDS21392
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HPRD |
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IMGT |
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EMBL |
AB006463
AB017361
AC109232
AF173010
AK010345
AK027915
AK152805
AK165472
BC003714
BC054385
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GenPept |
AAG38960
AAH03714
AAH54385
BAA36165
BAA74429
BAB26868
BAC25663
BAE31510
BAE38209
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