InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mink1

Summary

InnateDB Protein

IDBP-194773.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Mink1

Protein Name

misshapen-like kinase 1 (zebrafish)

Synonyms

B55; Map4k6; MINK; Ysk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072649

InnateDB Gene

IDBG-194763 (Mink1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001952	regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0022407	regulation of cell-cell adhesion
GO:0023014	signal transduction by phosphorylation
GO:0030334	regulation of cell migration
GO:0031532	actin cytoskeleton reorganization
GO:0045060	negative thymic T cell selection
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1355329

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt