InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atf7ip

Summary

InnateDB Protein

IDBP-194776.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atf7ip

Protein Name

activating transcription factor 7 interacting protein

Synonyms

2610204M12Rik; AM; Mcaf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032335

InnateDB Gene

IDBG-194774 (Atf7ip)

Protein Structure

UniProt Annotation

Function

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). May have ATPase activity. {ECO:0000269PubMed:10777215, ECO:0000269PubMed:14536086}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10777215}.

Disease Associations

Tissue Specificity

Ubiquitously expressed at all stages studied. {ECO:0000269PubMed:10777215}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0016887	ATPase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006200	ATP catabolic process
GO:0006306	DNA methylation
GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly