Version 5.4
Mus musculus Protein: Uba5
Summary
InnateDB Protein IDBP-194796.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Uba5
Protein Name ubiquitin-like modifier activating enzyme 5
Synonyms 5730525G14Rik; AW240750; Ube1dc1;
Species Mus musculus
Ensembl Protein ENSMUSP00000035166
InnateDB Gene IDBG-194794 (Uba5)
Protein Structure
UniProt Annotation
Function E1-like enzyme which activates UFM1 and SUMO2. {ECO:0000269PubMed:20018847}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes mainly in cytoplasm, while it mainly localizes to the nucleus in presence of SUMO2. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0048037 cofactor binding
GO:0071566 UFM1 activating enzyme activity
Biological Process
GO:0034976 response to endoplasmic reticulum stress
GO:0055114 oxidation-reduction process
GO:0071569 protein ufmylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016235 aggresome
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1913913
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
PFAM PF00899
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VE47
PhosphoSite PhosphoSite-Q8VE47
TrEMBL
UniProt Splice Variant
Entrez Gene 66663
UniGene Mm.398601
RefSeq NP_079968
MGI ID
MGI Symbol Uba5
OMIM
CCDS CCDS23457
HPRD
IMGT
EMBL AK017787 AK151823 AK152029 AK168907 BC019764 CH466560
GenPept AAH19764 BAB30933 BAE30720 BAE30888 BAE40721 EDL21084

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca