InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pebp1

Summary

InnateDB Protein

IDBP-194802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pebp1

Protein Name

phosphatidylethanolamine binding protein 1

Synonyms

HCNP; Pbp; Pbp1; Pbpr; Rkip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048425

InnateDB Gene

IDBG-194800 (Pebp1)

Protein Structure

UniProt Annotation

Function

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). {ECO:0000250}.HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

HCNP is expressed in brain. Increased expression in aged senescence-accelerated mice.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0001505	regulation of neurotransmitter levels
GO:0001933	negative regulation of protein phosphorylation
GO:0002026	regulation of the force of heart contraction
GO:0006979	response to oxidative stress
GO:0007286	spermatid development
GO:0007420	brain development
GO:0007568	aging
GO:0009408	response to heat
GO:0009611	response to wounding
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0010243	response to organonitrogen compound
GO:0010951	negative regulation of endopeptidase activity
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0042493	response to drug
GO:0042755	eating behavior
GO:0043409	negative regulation of MAPK cascade
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045471	response to ethanol
GO:0045840	positive regulation of mitosis
GO:0048240	sperm capacitation
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0051602	response to electrical stimulus
GO:0060409	positive regulation of acetylcholine metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0008021	synaptic vesicle
GO:0009986	cell surface
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043679	axon terminus
GO:0045177	apical part of cell