InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plbd1

Summary

InnateDB Protein

IDBP-194846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plbd1

Protein Name

phospholipase B domain containing 1

Synonyms

1100001H23Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032336

InnateDB Gene

IDBG-194844 (Plbd1)

Protein Structure

UniProt Annotation

Function

Exhibits weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. However, in view of the small size of the putative binding pocket, it has been proposed that it may act rather as an amidase or a peptidase (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0016787	hydrolase activity

Biological Process

GO:0008150	biological_process
GO:0016042	lipid catabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005764	lysosome

Protein Structure and Domains

PDB ID

MGI:1914107

InterPro

IPR007000 Phospholipase B-like

PFAM

PF04916

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VCI0

PhosphoSite

PhosphoSite-Q8VCI0

TrEMBL

UniProt Splice Variant

Entrez Gene

66857

UniGene

Mm.402180

RefSeq

NP_080082

MGI ID

MGI Symbol

Plbd1

OMIM

CCDS

CCDS20652

HPRD

IMGT

EMBL

AK003169 AK172021 BC019793

GenPept

AAH19793 BAB22618 BAE42780