Version 5.4
Mus musculus Protein: Gan
Summary
InnateDB Protein IDBP-194941.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gan
Protein Name giant axonal neuropathy
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000070168
InnateDB Gene IDBG-194939 (Gan)
Protein Structure
UniProt Annotation
Function Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. {ECO:0000250, ECO:0000269PubMed:16227972, ECO:0000269PubMed:16565160}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12147674}.
Disease Associations
Tissue Specificity Expressed in brain, heart and muscle (at protein level). {ECO:0000269PubMed:12147674}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0008219 cell death
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031463 Cul3-RING ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1890619
InterPro IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type
PFAM PF01344
PF07707
PF00651
PRINTS
PIRSF PIRSF037037
SMART SM00225
SM00612
SM00875
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CA72
PhosphoSite PhosphoSite-Q8CA72
TrEMBL
UniProt Splice Variant
Entrez Gene 209239
UniGene Mm.438845
RefSeq NP_001074620
MGI ID
MGI Symbol Gan
OMIM
CCDS CCDS40490
HPRD
IMGT
EMBL AC121116 AK039455 BC112432
GenPept AAI12433 BAC30353

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca