InnateDB Protein
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IDBP-194947.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Acpp
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Protein Name
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acid phosphatase, prostate
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Synonyms
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5\'-NT; A030005E02Rik; FRAP; Lap; PAP; Ppal;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000059889
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InnateDB Gene
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IDBG-194945 (Acpp)
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Protein Structure
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Function |
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). {ECO:0000250}.Isoform 2: the cellular form also has ecto-5'- nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. {ECO:0000269PubMed:18940592}.
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Subcellular Localization |
Isoform 1: Secreted {ECO:0000250}.Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is expressed in salivary gland, thymus and thyroid gland. Isoform 2 is widely expressed in prostate lobes, brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid and thymus. Locates to Schwann cells and fibroblasts. Expressed in peptidergic and non- peptidergic nociceptive (pain-sensing) neurons. Preferentially expressed in non-peptidergic doral root ganglia neurons. {ECO:0000269PubMed:17638863, ECO:0000269PubMed:18940592, ECO:0000269PubMed:20084276}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1928480
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InterPro |
IPR000560
Histidine phosphatase superfamily, clade-2
IPR029033
Histidine phosphatase superfamily
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PFAM |
PF00328
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CE08
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56318
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UniGene |
Mm.471376
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RefSeq |
NP_997551
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MGI ID |
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MGI Symbol |
Acpp
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OMIM |
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CCDS |
CCDS23460
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HPRD |
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IMGT |
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EMBL |
AF210243
AK029273
AK076383
BC139826
CT030733
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GenPept |
AAF23171
AAI39827
BAC26366
BAC36318
CAX15527
CAX15528
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