Mus musculus Protein: H2afj
Summary
InnateDB Protein IDBP-195010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2afj
Protein Name H2A histone family, member J
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000074142
InnateDB Gene IDBG-195008 (H2afj)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0008150 biological_process
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:3606192
InterPro IPR002119 Histone H2A
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS PR00620
PIRSF
SMART SM00414
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R1M2
PhosphoSite PhosphoSite-Q8R1M2
TrEMBL
UniProt Splice Variant
Entrez Gene 232440
UniGene Mm.401184
RefSeq NP_808356
MGI ID
MGI Symbol H2afj
OMIM
CCDS CCDS20654
HPRD
IMGT
EMBL AK053755 BC024397 BC099606
GenPept AAH24397 AAH99606 BAC35508