Version 5.4
Mus musculus Protein: Slc25a11
Summary
InnateDB Protein IDBP-195016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc25a11
Protein Name solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
Synonyms 2310022P18Rik; 2oxoc;
Species Mus musculus
Ensembl Protein ENSMUSP00000014750
InnateDB Gene IDBG-195014 (Slc25a11)
Protein Structure
UniProt Annotation
Function Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006810 transport
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915113
InterPro IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CR62
PhosphoSite PhosphoSite-Q9CR62
TrEMBL Q9CTC7
UniProt Splice Variant
Entrez Gene 67863
UniGene Mm.466994
RefSeq NP_077173
MGI ID
MGI Symbol Slc25a11
OMIM
CCDS CCDS24958
HPRD
IMGT
EMBL AK003957 AK009487 AK009824 AK168951 AL596117 BC003455 BC019631 CH466596
GenPept AAH03455 AAH19631 BAB23092 BAB26319 BAB26524 BAE40757 EDL12589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca