InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phlda3

Summary

InnateDB Protein

IDBP-195039.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phlda3

Protein Name

pleckstrin homology-like domain, family A, member 3

Synonyms

Tih1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040614

InnateDB Gene

IDBG-195037 (Phlda3)

Protein Structure

UniProt Annotation

Function

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12374806}. Membrane {ECO:0000269PubMed:12374806}; Peripheral membrane protein {ECO:0000269PubMed:12374806}.

Disease Associations

Tissue Specificity

Widely expressed in fetal tissues, with the exception of liver. Strongly expressed in adult skeletal muscle and lung. Widely expressed at lower levels in other adult tissues, with weakest expression in liver and spleen. {ECO:0000269PubMed:10594239}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	89 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0010314	phosphatidylinositol-5-phosphate binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065	positive regulation of apoptotic process
GO:0051898	negative regulation of protein kinase B signaling