InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tesc

Summary

InnateDB Protein

IDBP-195052.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tesc

Protein Name

tescalcin

Synonyms

1010001A17Rik; 2410011K10Rik; TE-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031304

InnateDB Gene

IDBG-195050 (Tesc)

Protein Structure

UniProt Annotation

Function

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269PubMed:14661968}.

Subcellular Localization

Nucleus. Cytoplasm. Membrane. Cell membrane {ECO:0000250}. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Colocalizes with SLC9A1 at the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in embryonic, newborn and adult testis, but not in prepubertal testis. Expressed in the embryonic testis during testis determination but is not expressed at any time in the embryonic ovary. In embryonic testis, expression is restricted to the testis cords and is seen in both Sertoli cells and germ cells. Expression is excluded from the myoid cells which surround the cords. Expressed in the embryonic adrenal after the initial stages of differentiation. Expressed at a lower level in the embryonic brain, heart and lung but not in liver or gut. May be expressed at a very low level in the embryonic kidney. In the embryonic brain, expressed in the nasal placode and in fibers extending from the olfactory epithelium to the primordial olfactory bulb. In adults, expressed in the heart, and weakly in the brain and kidney. Highly expressed in terminally differentiated megakaryocytes (at protein level). Not detected in fetal liver cells (at protein level). {ECO:0000269PubMed:11145610, ECO:0000269PubMed:14661968, ECO:0000269PubMed:17717601, ECO:0000269PubMed:19345287}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004860	protein kinase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019212	phosphatase inhibitor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0006883	cellular sodium ion homeostasis
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010628	positive regulation of gene expression
GO:0030219	megakaryocyte differentiation
GO:0030854	positive regulation of granulocyte differentiation
GO:0032417	positive regulation of sodium:proton antiporter activity
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0043086	negative regulation of catalytic activity
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050821	protein stabilization
GO:0051604	protein maturation
GO:0071300	cellular response to retinoic acid
GO:0072661	protein targeting to plasma membrane