InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcg2

Summary

InnateDB Protein

IDBP-195072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcg2

Protein Name

phospholipase C, gamma 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079991

InnateDB Gene

IDBG-195070 (Plcg2)

Protein Structure

UniProt Annotation

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0002316	follicular B cell differentiation
GO:0006629	lipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007165	signal transduction
GO:0009395	phospholipid catabolic process
GO:0010468	regulation of gene expression
GO:0030183	B cell differentiation
GO:0032237	activation of store-operated calcium channel activity
GO:0032496	response to lipopolysaccharide
GO:0032959	inositol trisphosphate biosynthetic process
GO:0035556	intracellular signal transduction
GO:0043069	negative regulation of programmed cell death
GO:0045087	innate immune response (InnateDB)
GO:0050852	T cell receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:0051209	release of sequestered calcium ion into cytosol

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97616

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR000980 SH2 domain
IPR001192 Phosphoinositide phospholipase C family
IPR001452 SH3 domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM