InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnnt2

Summary

InnateDB Protein

IDBP-195090.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnnt2

Protein Name

troponin T2, cardiac

Synonyms

cTnT; Tnt;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027671

InnateDB Gene

IDBG-195088 (Tnnt2)

Protein Structure

UniProt Annotation

Function

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005523	tropomyosin binding
GO:0030172	troponin C binding
GO:0031013	troponin I binding

Biological Process

GO:0006936	muscle contraction
GO:0006937	regulation of muscle contraction
GO:0007507	heart development
GO:0008016	regulation of heart contraction
GO:0030049	muscle filament sliding
GO:0032780	negative regulation of ATPase activity
GO:0032781	positive regulation of ATPase activity
GO:0045214	sarcomere organization
GO:0051592	response to calcium ion
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis