Version 5.4
Mus musculus Protein: Tacr3
Summary
InnateDB Protein IDBP-195099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tacr3
Protein Name tachykinin receptor 3
Synonyms Nk3r; Nkr; Tac3r;
Species Mus musculus
Ensembl Protein ENSMUSP00000029822
InnateDB Gene IDBG-195097 (Tacr3)
Protein Structure
UniProt Annotation
Function This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004995 tachykinin receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0007568 aging
GO:0010460 positive regulation of heart rate
GO:0032355 response to estradiol
GO:0042053 regulation of dopamine metabolic process
GO:0042220 response to cocaine
GO:0042538 hyperosmotic salinity response
GO:0043278 response to morphine
GO:0045777 positive regulation of blood pressure
GO:0060259 regulation of feeding behavior
GO:0070474 positive regulation of uterine smooth muscle contraction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032590 dendrite membrane
GO:0032809 neuronal cell body membrane
Protein Structure and Domains
PDB ID MGI:892968
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR001013 Neurokinin NK3 receptor
IPR001681 Neurokinin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR01012
PR01026
PR00244
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47937
PhosphoSite PhosphoSite-P47937
TrEMBL
UniProt Splice Variant
Entrez Gene 21338
UniGene Mm.103810
RefSeq NP_067357
MGI ID
MGI Symbol Tacr3
OMIM
CCDS CCDS17852
HPRD
IMGT
EMBL AF233341 AK031898 AK046424 L27827 X87823
GenPept AAA17893 AAF62517 BAC27596 BAC32723 CAA61088

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca