InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Inhbc

Summary

InnateDB Protein

IDBP-195102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Inhbc

Protein Name

inhibin beta-C

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026472

InnateDB Gene

IDBG-195100 (Inhbc)

Protein Structure

UniProt Annotation

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly expressed in the adult liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0008083	growth factor activity

Biological Process

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:105932

InterPro

IPR001318 Inhibin, beta C subunit
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00019

PRINTS

PR00672
PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt