Version 5.4
Mus musculus Protein: Man2a2
Summary
InnateDB Protein IDBP-195122.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Man2a2
Protein Name mannosidase 2, alpha 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000095949
InnateDB Gene IDBG-195120 (Man2a2)
Protein Structure
UniProt Annotation
Function Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559 alpha-mannosidase activity
GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0008270 zinc ion binding
GO:0015923 mannosidase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
GO:0006486 protein glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2150656
InterPro IPR000602 Glycoside hydrolase family 38, N-terminal domain
IPR011013 Galactose mutarotase-like domain
IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
IPR011682 Glycosyl hydrolase family 38, C-terminal
IPR015341 Glycoside hydrolase, family 38, central domain
IPR028995 Glycoside hydrolase, families 57/38, central domain
PFAM PF01074
PF07748
PF09261
PRINTS
PIRSF
SMART SM00872
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BRK9
PhosphoSite PhosphoSite-Q8BRK9
TrEMBL Q9WU23
UniProt Splice Variant
Entrez Gene 140481
UniGene Mm.269245
RefSeq NP_766491
MGI ID
MGI Symbol Man2a2
OMIM
CCDS CCDS57556
HPRD
IMGT
EMBL AC136740 AF107018 AK029913 AK044028 AK137205 BC055006 CH466543 DQ631806
GenPept AAD20813 AAH55006 ABG02551 BAC31745 BAE23268 EDL06997

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca