Version 5.4
Mus musculus Protein: Nudc
Summary
InnateDB Protein IDBP-195164.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nudc
Protein Name nuclear distribution gene C homolog (Aspergillus)
Synonyms SIG-92; Silg92;
Species Mus musculus
Ensembl Protein ENSMUSP00000030665
InnateDB Gene IDBG-195162 (Nudc)
Protein Structure
UniProt Annotation
Function Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Note=A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non- migrating cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in fetal and adult brain, in particular in the ventricular zone of the embryonic forebrain and in the embryonic cortical plate. Highly expressed in brain cortex from new born and adult mice. Detected in the choroid plexus and in ependymal cells in embryonic brain. {ECO:0000269PubMed:11734602, ECO:0000269PubMed:9601647}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
Protein Structure and Domains
PDB ID MGI:106014
InterPro IPR007052 CS domain
IPR008978 HSP20-like chaperone
PFAM PF04969
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35685
PhosphoSite PhosphoSite-O35685
TrEMBL
UniProt Splice Variant
Entrez Gene 18221
UniGene Mm.69
RefSeq NP_035078
MGI ID 2CR0
MGI Symbol Nudc
OMIM
CCDS CCDS18750
HPRD
IMGT
EMBL AK032673 AK146323 BC011253 X81443 Y15522
GenPept AAH11253 BAC27981 BAE27078 CAA57201 CAA75677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca