InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Twsg1

Summary

InnateDB Protein

IDBP-195175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Twsg1

Protein Name

twisted gastrulation homolog 1 (Drosophila)

Synonyms

1810013J15Rik; 9030422N06Rik; AW552143; D17Ertd403e; Tsg; Twg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024906

InnateDB Gene

IDBG-195171 (Twsg1)

Protein Structure

UniProt Annotation

Function

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development. {ECO:0000269PubMed:11260715, ECO:0000269PubMed:12119341, ECO:0000269PubMed:15843411, ECO:0000269PubMed:16905550}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in lymph node, liver, kidney, and lung. Expression in the kidney was stronger in the medulla than in the cortex, particularly in the cells surrounding the medullary tubules. Expressed in growth plate cartilage of long bones, ribs, and digits and to a lesser extent also in the resting zone of the epiphysis, trabecular bone, and vertebral cartilage. Expression seems to be absent from other skeletal tissues including muscle, skin, and fibroblasts. {ECO:0000269PubMed:16905550}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001503	ossification
GO:0001707	mesoderm formation
GO:0007435	salivary gland morphogenesis
GO:0009888	tissue development
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0030900	forebrain development
GO:0043010	camera-type eye development
GO:0045668	negative regulation of osteoblast differentiation